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| Product Name: | DHEA-S | | Synonyms: | Formylisoglutamic acid;DEHYDROEPIANDROSTERONESULPHATE;[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate;sulfuric acid [(3S,8R,9S,10R,13S,14S)-17-keto-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] ester;(3β)-3-(Sulfooxy)androst-5-en-17-one;Prasterone Sulfate Sports Nutrition Supplements Prasterone Sodium Sulfate 651-48-9;Androst-5-en-17-one, 3-(sulfooxy)-, (3β)-;Abiraterone Impurity 73 | | CAS: | 651-48-9 | | MF: | C19H28O5S | | MW: | 368.49 | | EINECS: | | | Product Categories: | | | Mol File: | 651-48-9.mol |  |
| | DHEA-S Chemical Properties |
| Boiling point | 468.81°C (rough estimate) | | density | 1.1763 (rough estimate) | | refractive index | 1.5300 (estimate) | | Melting point | 190-192 °C | | pKa | -3.51±0.18(Predicted) | | form | Solid | | color | White to off-white |
| | DHEA-S Usage And Synthesis |
| Uses | Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3]. | | Definition | ChEBI: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone. | | in vivo | DHEAS chronic administration produces a dose-dependent effect on performance[3].
| Animal Model: | Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g)[3]. | | Dosage: | 5, 10, or 20 mg/kg. | | Administration: | Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing. | | Result: | Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle. |
| | IC 50 | Human Endogenous Metabolite | | References | [1] E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. DOI:10.1073/pnas.95.8.4089
[2] C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. DOI:10.1016/s0039-128x(99)00046-x
[3] Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. DOI:10.1089/089771503322385791 |
| | DHEA-S Preparation Products And Raw materials |
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