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| | Diethyl(3-pyridyl)borane Basic information |
| | Diethyl(3-pyridyl)borane Chemical Properties |
| Melting point | 172-175 °C(lit.) | | Boiling point | 205.9±22.0 °C(Predicted) | | density | 0.86±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 4.40±0.12(Predicted) | | form | Solid | | color | White to Almost white | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C9H14BN/c1-3-10(4-2)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 | | InChIKey | OJKBCQOJVMAHDX-UHFFFAOYSA-N | | SMILES | C1=NC=CC=C1B(CC)CC | | CAS DataBase Reference | 89878-14-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Diethyl(3-pyridyl)borane Usage And Synthesis |
| Chemical Properties | White to yellow solid | | Uses | Reactant for: preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents, N-Methylation reactions of the pyridyl group, Palladium catalyzed amination reactions, intramolecular Heck reactions, Coupling reactions and Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling. | | Uses | Reactant for:
- Preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
- N-Methylation reactions of the pyridyl group
- Palladium catalyzed amination reactions
- Intramolecular Heck reactions
- Coupling reactions
- Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling
| | Uses | suzuki reaction | | reaction suitability | reagent type: reductant | | Synthesis | Reaction temperature 0 ~ 5 , reaction time 6h, diethylmethoxyborane drop time 30 min, material ratio n (3-bromopyridine): n (diethylmethoxyborane) for 0.9:1.0, material ratio n (isopropylmagnesium chloride): n (diethylmethoxyborane) for 1.0:1.0. In the optimal conditions of the process to produce the product is a white solid, melting point of 172 ~ 175 , yield of more than 81%. Under the optimal process conditions, the product is white solid with a melting point of 172175 and a yield of more than 81%.
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| | Diethyl(3-pyridyl)borane Preparation Products And Raw materials |
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