Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)-

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Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- Basic information
Product Name:Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)-
Synonyms:Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)-;ARN25068
CAS:2649882-80-2
MF:C19H18N6S
MW:362.45
EINECS:
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Mol File:2649882-80-2.mol
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- Structure
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- Chemical Properties
Boiling point 678.9±65.0 °C(Predicted)
density 1.478±0.06 g/cm3(Predicted)
pka14.22±0.10(Predicted)
form Solid
color White to off-white
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MSDS Information
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- Usage And Synthesis
UsesARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1].
References[1] Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054. DOI:10.1016/j.ejmech.2021.114054
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- Preparation Products And Raw materials
Tag:Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)-(2649882-80-2) Related Product Information
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