| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
18108108965 18108108965 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Abiraterone acetate-d4
CAS:2122245-63-8
Purity:98% HPLC Package:1mg;5mg;10mg;50mg
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| Company Name: |
CHINA ISOTOPE CO., LIMITED
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| Tel: |
02151600108 13062666369 |
| Email: |
info@isotopechem.com |
| Products Intro: |
Product Name:Abiraterone Acetate-d4
CAS:2122245-63-8
Purity:Purity: >=98% Package:1mg Remarks:CA22096
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Abiraterone Acetate-d4
CAS:2122245-63-8
Purity:95% Package:500μg;1mg;5mg
|
| Company Name: |
TLC Pharmaceutical Standards Ltd.
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| Tel: |
18012923235 18012923235 |
| Email: |
chinasales04@tlcstandards.com.cn |
| Products Intro: |
Product Name:Abiraterone-d4 Acetate
CAS:2122245-63-8
Purity:95%+ HPLC Package:10mg;25mg;50mg;100mg
|
| Company Name: |
TLC Pharmaceutical Standards Ltd.
|
| Tel: |
18012923235 |
| Email: |
chinasales04@tlcstandards.com.cn |
| Products Intro: |
Product Name:Abiraterone-d4 Acetate
CAS:2122245-63-8
Purity:95%+ HPLC Package:10mg;25mg;50mg;100mg
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| | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl-2,4,5,6-d4)-, 3-acetate, (3β)- Basic information |
| Product Name: | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl-2,4,5,6-d4)-, 3-acetate, (3β)- | | Synonyms: | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl-2,4,5,6-d4)-, 3-acetate, (3β)-;(3β)-17-(3-pyridinyl-d4)-androsta-5,16-dien-3-ol,acetateester | | CAS: | 2122245-63-8 | | MF: | C26H33NO2 | | MW: | 391.56 | | EINECS: | | | Product Categories: | | | Mol File: | 2122245-63-8.mol |  |
| | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl-2,4,5,6-d4)-, 3-acetate, (3β)- Chemical Properties |
| solubility | Methanol: Soluble | | form | A solid |
| | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl-2,4,5,6-d4)-, 3-acetate, (3β)- Usage And Synthesis |
| Description | Abiraterone acetate-d4 is intended for use as an internal standard for the quantification of abiraterone acetate by GC- or LC-MS. Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17α-hydroxylase activities, respectively).1 It is also a prodrug form of abiraterone .2 Abiraterone acetate reduces plasma testosterone levels, increases plasma luteinizing hormone levels, and reduces ventral prostate, seminal vesicle, testis, and kidney weight in mice when administered at doses of 0.1 and 0.5 mmol/kg per day. It also reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the culture supernatant of infected Vero E6 cells (EC90 = 8.4 μM) and is active in a plaque reduction assay (EC50 = 1.94 μM).3 Formulations containing abiraterone acetate have been used in combination therapy for the treatment of metastatic castration-resistant prostate cancer. | | References | 1. Potter, G.A., Barrie, S.E., Jarman, M., et al. Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer J. Med. Chem. 38(13),2463-2471(1995).
2. Barrie, S.E., Potter, G.A., Goddard, P.M., et al. Pharmacology of novel steroidal inhibitors of cytochrome P45017α (17α-hydroxylase/C17-20 lyase) J. Steroid Biochem. Mol. Biol. 50(5-6),267-273(1994).
3. Yuan, S., Chan, J.F.W., Chik, K.K.H., et al. Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system Pharmacol. Res. 159,104960(2020). |
| | Androsta-5,16-dien-3-ol, 17-(3-pyridinyl-2,4,5,6-d4)-, 3-acetate, (3β)- Preparation Products And Raw materials |
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