1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-

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Company Name: Shanghai Beckham Medical Technology Co., Ltd  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
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1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- manufacturers

  • MC2590
  • MC2590 pictures
  • $208.00
  • 2026-08-30
  • CAS:2284460-01-9
  • Purity: 99.64%
  • Supply Ability: 10g
1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Basic information
Product Name:1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-
Synonyms:1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-;MC2590
CAS:2284460-01-9
MF:C20H17N3O3
MW:347.37
EINECS:
Product Categories:
Mol File:2284460-01-9.mol
1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Structure
1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Chemical Properties
density 1.362±0.06 g/cm3(Predicted)
pka8.63±0.23(Predicted)
Safety Information
MSDS Information
1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Usage And Synthesis
UsesMC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC50s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC50s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction[1].
IC 50HDAC1: 0.098 μM (IC50); HDAC2: 0.156 μM (IC50); HDAC3: 0.039 μM (IC50); HDAC6: 0.015 μM (IC50); HDAC8: 0.047 μM (IC50); HDAC10: 0.071 μM (IC50); HDAC4: 2.73 μM (IC50); HDAC5: 1.35 μM (IC50); HDAC7: 2.06 μM (IC50); HDAC9: 2.79 μM (IC50); HDAC11: 3.98 μM (IC50)
References[1] Elisabetta Di Bello, et al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022. DOI:10.1016/j.ejmech.2022.115022
1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Preparation Products And Raw materials
Tag:1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-(2284460-01-9) Related Product Information
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