2-氯-N1,N4-双(4-(4,5-二氢-1H-咪唑-2-基)苯基)对苯二甲酰胺
| 中文名称 | 2-氯-N1,N4-双(4-(4,5-二氢-1H-咪唑-2-基)苯基)对苯二甲酰胺 |
|---|---|
| 中文同义词 | 2-氯-N1,N4-双(4-(4,5-二氢-1H-咪唑-2-基)苯基)对苯二甲酰胺;化合物NSC-60339 |
| 英文名称 | NSC 38280 |
| 英文同义词 | NSC 38280;2-Chloro-N,N'-bis[4-(2-imidazolin-2-yl)phenyl]terephthalamide;1,4-Benzenedicarboxamide, 2-chloro-N,N'-bis(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)- (9ci);2-Chloro-4',4''-di-2-imidazolin-2-yl-terephthalanilide;Hr 2198;Nsc 60339;Terephthalanilide, 2-chloro-4',4''-di-2-imidazolin-2-yl- (8ci);Wander |
| CAS号 | 70-09-7 |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 70-09-7.mol |
| 结构式 |  |
2-氯-N1,N4-双(4-(4,5-二氢-1H-咪唑-2-基)苯基)对苯二甲酰胺 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：5 mg/mL（10.27 mM） |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
NSC-60339 是外排泵的抑制剂和 AcrAB-TolC 的底物，是聚对苯二甲酸衍生物，是一种潜在的癌症化疗化合物。
NSC 60339 has been correlated with the sensitivity, resistance, or cross-resistance of 7 tumor lines to phthalanilide treatment in vivo. The sensitive tumors (L1210, L1210/MTX, L1210/ara-C, and P815) rapidly takes up the drug and retained it primarily as lipid-bound drug for the 24-hr experimental period. The resistant tumor, L1210/NSC 60339, and 2 cross-resistant tumors, P388/VCR and P815/VLB, took up as much drug as the sensitive tumors did by 0.5 hr, but there was an efflux of lipid-bound drug from these resistant tumors by 24 hr.