| Company Name: |
CHINA ISOTOPE CO., LIMITED
|
| Tel: |
02151600108 13062666369 |
| Email: |
info@isotopechem.com |
| Products Intro: |
Product Name:Radotinib-d6
CAS:2754051-83-5
Purity:Purity: >=98% Package:1mg Remarks:CA30767
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Radotinib-d6
CAS:2754051-83-5
Purity:95% Package:1mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Radotinib-d6
CAS:2754051-83-5
|
|
| | Radotinib-d6 Basic information |
| Product Name: | Radotinib-d6 | | Synonyms: | 2,3,6-trideuterio-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-5-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]-4-(trideuteriomethyl)benzamide | | CAS: | 2754051-83-5 | | MF: | C27H15D6F3N8O | | MW: | 536.54 | | EINECS: | | | Product Categories: | | | Mol File: | 2754051-83-5.mol |  |
| | Radotinib-d6 Chemical Properties |
| density | 1.406±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMSO: soluble |
| | Radotinib-d6 Usage And Synthesis |
| Uses | Radotinib-d6 is deuterium labeled Radotinib. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kim SH, et al. Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors. Haematologica. 2014 Jul;99(7):1191-6. DOI:10.3324/haematol.2013.096776
[3] M S ZABRISKIE. Radotinib is an effective inhibitor of native and kinase domain-mutant BCR-ABL1[J]. Leukemia, 2015, 29 9: 1939-1942. DOI: 10.1038/leu.2015.42
[4] SOOK-KYOUNG HEO. Radotinib Induces Apoptosis of CD11b+ Cells Differentiated from Acute Myeloid Leukemia Cells.[J]. PLoS ONE, 2015: e0129853. DOI: 10.1371/journal.pone.0129853 |
| | Radotinib-d6 Preparation Products And Raw materials |
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