akuammine manufacturers
- Akuammine
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- $1660.00
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2026-05-11
- CAS:3512-87-6
- Purity:
- Supply Ability: 10g
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| | akuammine Basic information |
| Product Name: | akuammine | | Synonyms: | akuammine;(2S,3E,7aα,12aα,12bβ,15R)-3-Ethylidene-1,3,4,6,7,12b-hexahydro-9-hydroxy-12-methyl-2H,12H-12a,2,7a-(epoxyethanylidene)indolo[2,3-a]quinolizine-15-carboxylic acid methyl ester;Vincamajoridine;2H,12H-12a,2,7a-(Epoxyethanylylidene)indolo[2,3-a]quinolizine-15-carboxylic acid, 3-ethylidene-1,3,4,6,7,12b-hexahydro-9-hydroxy-12-methyl-, methyl ester, (2S,3E,7aS,12aS,12bS,15R)- | | CAS: | 3512-87-6 | | MF: | C22H26N2O4 | | MW: | 382.45 | | EINECS: | | | Product Categories: | | | Mol File: | 3512-87-6.mol |  |
| | akuammine Chemical Properties |
| Melting point | 316 °C | | Boiling point | 564.0±50.0 °C(Predicted) | | alpha | D16 -105.3° (c = 1.31 in pyridine) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol | | form | A crystalline solid | | pka | 7.5(at 25℃) | | Optical Rotation | -73.420 (c 0.8716, CHCl3) |
| | akuammine Usage And Synthesis |
| Uses | Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg. | | References | [1] Creed, et al. Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloids. J. Nat. Prod. 84(1), 71-80 (2021). |
| | akuammine Preparation Products And Raw materials |
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