5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile

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5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Suppliers list
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5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile manufacturers

  • PYR01
  • PYR01 pictures
  • 2026-07-27
  • CAS:2560576-15-8
  • Purity:
  • Supply Ability: 10g
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Basic information
Product Name:5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile
Synonyms:5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile
CAS:2560576-15-8
MF:C21H13F7N4O3
MW:502.34
EINECS:
Product Categories:
Mol File:2560576-15-8.mol
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Structure
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Chemical Properties
density 1.53±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka9.88±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Usage And Synthesis
UsesPYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV[1].
References[1] Carl J Balibar, et al. Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med. 2023 Feb 22;15(684):eabn2038. DOI:10.1126/scitranslmed.abn2038
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Preparation Products And Raw materials
Tag:5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile(2560576-15-8) Related Product Information
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Ritonavir PLERIXAFOR Gag-Pol polyprotein, HIV (440a.a, His) P24 protein, HIV-1 (BAH97658, HIS) Rev Protein, HIV-1 group M subtype C (GST)