N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide

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N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide Basic information
Product Name:N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide
Synonyms:N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide
CAS:2768005-77-0
MF:C27H22ClN7O3S
MW:560.03
EINECS:
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Mol File:2768005-77-0.mol
N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide Structure
N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide Chemical Properties
Boiling point 810.1±75.0 °C(Predicted)
density 1.456±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka6.54±0.40(Predicted)
Safety Information
MSDS Information
N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide Usage And Synthesis
UsesPI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 μM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].
References[1] Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271. DOI:10.1016/j.bmcl.2021.128271
N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide Preparation Products And Raw materials
Tag:N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide(2768005-77-0) Related Product Information
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