L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2)

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L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2) Basic information
Product Name:L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2)
Synonyms:L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2);(S)-2-Amino-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoic acid dihydrochloride
CAS:2707535-88-2
MF:C13H19ClN2O3.2ClH
MW:359.68
EINECS:
Product Categories:
Mol File:2707535-88-2.mol
L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2) Structure
L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2) Chemical Properties
solubility DMSO: soluble
Methanol: soluble
Water: soluble
Safety Information
MSDS Information
L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2) Usage And Synthesis
UsesMonohydroxy melphalan hydrochloride (Hydroxymelphalan hydrochloride) is a degradation product of Melphalan (HY-17575), obtained through the hydrolysis of Melphalan in aqueous solutions (including cell culture media and human plasma)[1].
References[1] Bosanquet A G, et al. Degradation of melphalan in vitro: rationale for the use of continuous exposure in chemosensitivity assays[J]. Cancer chemotherapy and pharmacology, 1988, 21: 211-215. DOI:10.1007/BF00262772
[2] KATHERINE A GOULD M J T Cally Nixon. p53 elevation in relation to levels and cytotoxicity of mono- and bifunctional melphalan-DNA adducts.[J]. Molecular Pharmacology, 2004, 66 5: 1301-1309. DOI: 10.1124/mol.104.000596
[3] ASMAE MIRKOU . Assays for the quantification of melphalan and its hydrolysis products in human plasma by liquid chromatography–tandem mass spectrometry[J]. Journal of Chromatography B, 2009, 877 27: Pages 3089-3096. DOI: 10.1016/j.jchromb.2009.07.033
L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2) Preparation Products And Raw materials
Tag:L-Phenylalanine, 4-[(2-chloroethyl)(2-hydroxyethyl)amino]-, hydrochloride (1:2)(2707535-88-2) Related Product Information
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