5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine

Request For Quotation
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Suppliers list
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine manufacturers

  • ATR-IN-29
  • ATR-IN-29 pictures
  • 2026-04-20
  • CAS:2761193-67-1
  • Purity:
  • Supply Ability: 10g
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Basic information
Product Name:5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine
Synonyms:5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine;ATR-IN-29
CAS:2761193-67-1
MF:C19H22N8O
MW:378.43
EINECS:
Product Categories:
Mol File:2761193-67-1.mol
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Structure
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Chemical Properties
density 1.48±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka11.25±0.10(Predicted)
Safety Information
MSDS Information
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Usage And Synthesis
UsesATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC50 value of 1 nM. ATR-IN-29 shows antiproliferative activity[1].
in vivo

ATR-IN-29 (10 mg/kg; p.o.; once) shows good pharmacokinetic parameters with t1/2 of 1.64 h, Cmax of 9343 ng/mL, AUC0-t of 98507 ng·h/mL, AUC0-inf of 98517 ng·h/mL in CD-1 (ICR) mice[1].

IC 50ATR: 1 nM (IC50)
References[1] Sui Xiong Cai, et al. Substituted imidazo[1,5-b]pyridazine compounds as kinase inhibitors and use thereof. WO2022135560A1.
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Preparation Products And Raw materials
Tag:5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine(2761193-67-1) Related Product Information
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine BAY-1895344 BAY1895344 HCl Imidazo[1,5-b]pyridazine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)- Elimusertib (hydrochloride) AZD-1390