| Company Name: |
Twochem Co.Ltd. |
| Tel: |
021-58111628 15800915896 |
| Email: |
sales@twochem.com |
4-amidinoindan-1-one 2'-amidinohydrazone manufacturers
- Sardomozide
-
- $1520.00
-
2026-04-20
- CAS:149400-88-4
- Purity:
- Supply Ability: 10g
- Sardomozide
-
- $1520.00
-
2025-08-22
- CAS:149400-88-4
- Purity:
- Supply Ability: 10g
|
| | 4-amidinoindan-1-one 2'-amidinohydrazone Basic information |
| Product Name: | 4-amidinoindan-1-one 2'-amidinohydrazone | | Synonyms: | 4-amidinoindan-1-one 2'-amidinohydrazone;(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide;(E)-2-(4-carbaMiMidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinec;CGP 48664;SAM 486A;2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide;Hydrazinecarboximidamide, 2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]-;Sardomozide (CGP-48664 | | CAS: | 149400-88-4 | | MF: | C11H14N6 | | MW: | 230.27 | | EINECS: | | | Product Categories: | | | Mol File: | 149400-88-4.mol |  |
| | 4-amidinoindan-1-one 2'-amidinohydrazone Chemical Properties |
| Boiling point | 438.8±55.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO | | pka | 11.54±0.20(Predicted) |
| | 4-amidinoindan-1-one 2'-amidinohydrazone Usage And Synthesis |
| Uses | Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM. | | Biological Activity | Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with IC50 of 5 nM. | | in vitro | Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells. | | target | | | References | [1] Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. PMID:8205541
[2] Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90. PMID:9731498 |
| | 4-amidinoindan-1-one 2'-amidinohydrazone Preparation Products And Raw materials |
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