- β-NETA
-
- $30.00
-
2026-05-25
- CAS:31059-54-8
- Purity: 98.00%
- Supply Ability: 10g
- β-NETA
-
- $30.00
-
2026-05-25
- CAS:31059-54-8
- Purity: 98.00%
- Supply Ability: 10g
|
| | 2-naphthoylethyltrimethylammonium Basic information |
| Product Name: | 2-naphthoylethyltrimethylammonium | | Synonyms: | 2-naphthoylethyltrimethylammonium;2-(beta-Naphthoyl)ethyltrimethylammonium iodide;2-Dimethylaminoethyl 2-naphthyl ketone methiodide;trimethyl-(3-naphthalen-2-yl-3-oxopropyl)azanium:iodide;β-NETA;α-NETA;histamine,Cholinesterase (ChE),Apoptosis,ChE,β-NETA,KCl,β NETA,ChA,choline acetyltransferase,βNETA,Inhibitor,cholinesterase,inhibit;alpha-NETA, Fluorescent ChAT inhibitor | | CAS: | 31059-54-8 | | MF: | C16H20NO.I | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 31059-54-8.mol |  |
| | 2-naphthoylethyltrimethylammonium Chemical Properties |
| storage temp. | Store at -20°C, protect from light, stored under nitrogen | | solubility | DMSO: 3mg/ml; Methanol: Soluble | | form | A solid | | color | White to off-white |
| | 2-naphthoylethyltrimethylammonium Usage And Synthesis |
| Description | Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture. | | Uses | Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis. α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM). This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase. α-NETA is commonly used in cells in culture.[Cayman Chemical] | | Uses | alpha-NETA is a fluorescent choactase inhibitor. | | IC 50 | AChE | | References | [1] B V SASTRY. 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1988, 245 1: 72-80.
[2] B.V. RAMA SASTRY. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compounds[J]. Pharmacological research communications, 1988, 20 9: Pages 751-771. DOI: 10.1016/s0031-6989(88)80715-x
[3] B.M. EATON S. R S. Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells[J]. Placenta, 1998, 19 8: Pages 663-669. DOI: 10.1016/s0143-4004(98)90028-5
[4] DEBORAH A SAWATZKY. Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells.[J]. American journal of physiology. Lung cellular and molecular physiology, 2003, 285 6: L1296-304. DOI: 10.1152/ajplung.00107.2003 |
| | 2-naphthoylethyltrimethylammonium Preparation Products And Raw materials |
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