|
|
| | EGFR/AURKB-IN-1 Basic information |
| Product Name: | EGFR/AURKB-IN-1 | | Synonyms: | EGFR/AURKB-IN-1;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-(1-methyl-1H-pyrazol-5-yl)-N-[4-(phenylmethoxy)phenyl]- | | CAS: | 3008543-34-5 | | MF: | C23H20N6O | | MW: | 396.45 | | EINECS: | | | Product Categories: | | | Mol File: | 3008543-34-5.mol |  |
| | EGFR/AURKB-IN-1 Chemical Properties |
| density | 1.322±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 12.606±0.50(predicted) | | color | Off-white to light yellow |
| | EGFR/AURKB-IN-1 Usage And Synthesis |
| Uses | EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research[1]. | | References | [1] Kurup S, et al. Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer. Bioorg Med Chem Lett. 2024 Jan 8:129612. DOI:10.1016/j.bmcl.2024.129612 |
| | EGFR/AURKB-IN-1 Preparation Products And Raw materials |
|