CHS-828 nicotinate

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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CHS-828 nicotinate Basic information
Product Name:CHS-828 nicotinate
Synonyms:CHS-828 nicotinate;3-Pyridinecarboxylic acid, mixt. with N′′-[6-(4-chlorophenoxy)hexyl]-N-cyano-N′-4-pyridinylguanidine
CAS:1160589-73-0
MF:C19H22ClN5O.C6H5NO2
MW:494.97
EINECS:
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Mol File:1160589-73-0.mol
CHS-828 nicotinate Structure
CHS-828 nicotinate Chemical Properties
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CHS-828 nicotinate Usage And Synthesis
UsesCHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity[1].
References[1] Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88. DOI:10.1128/MCB.00112-09
[2] Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012 Jun 22;287(26):22408-17. DOI:10.1074/jbc.M112.357301
CHS-828 nicotinate Preparation Products And Raw materials
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