3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)-

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3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- Suppliers list
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3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- Basic information
Product Name:3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)-
Synonyms:3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)-;IDOR-1117-2520
CAS:2737274-49-4
MF:C25H32N4O3
MW:436.55
EINECS:
Product Categories:
Mol File:2737274-49-4.mol
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- Structure
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- Chemical Properties
Boiling point 573.9±60.0 °C(predicted)
density 1.193±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.24±0.29(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- Usage And Synthesis
UsesIDOR-1117-2520 is a potent and selective antagonist of CCR6. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 can be used for research of autoimmune diseases[1].
References[1] Meyer EA, et al. Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases. J Med Chem. 2024 May 10. DOI:10.1021/acs.jmedchem.4c00186
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- Preparation Products And Raw materials
Tag:3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)-(2737274-49-4) Related Product Information
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- tert-butyl (R)-3-((4-bromophenyl)(hydroxy)(5-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)pyridin-3-yl)methyl)-3-methylazetidine-1-carboxylate (R)-2-(3-(5-((4-bromophenyl)(1,3-dimethylazetidin-3-yl)(hydroxy)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)propan-2-ol MCP-2/CCL8 Protein, Human MIP-3 beta/CCL19 Protein, Mouse RANTES/CCL5 Protein, Human