DD-03-156

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DD-03-156 Suppliers list
Company Name: Lucheng (Shenzhen) Technology Co., Ltd.  
Tel: 13128698830
Email:
DD-03-156 Basic information
Product Name:DD-03-156
Synonyms:DD-03-156
CAS:2769753-69-5
MF:C53H62F3N9O8S3
MW:1106.31
EINECS:
Product Categories:
Mol File:2769753-69-5.mol
DD-03-156 Structure
DD-03-156 Chemical Properties
density 1.344±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka6.62±0.10(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
DD-03-156 Usage And Synthesis
UsesDD-03-156 is a potent and selective degrader of CDK17 and LIMK2. The selectivity and potency of DD-03-156 is exquisite and makes an advanced starting point for the development of a chemical probe for the degradation of CDK17 (Blue: VHL ligand (HY-112078), Black: linker HY-124380 (HY-124380)；Pink: BRAF inhibitor (HY-14660))[1].
IC 50LIMK2
References[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. DOI:10.1016/j.cell.2020.10.038
DD-03-156 Preparation Products And Raw materials
Tag:DD-03-156(2769753-69-5) Related Product Information
DD-03-156 Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(2-piperidinyl)-4-thiazolyl]-2-fluorophenyl]-2,5-difluoro- GSK2008607 dTAGV-1 CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9)