STING agonist-31

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STING agonist-31 Basic information
Product Name:STING agonist-31
Synonyms:STING agonist-31
CAS:2719001-44-0
MF:
MW:0
EINECS:
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Mol File:Mol File
STING agonist-31 Structure
STING agonist-31 Chemical Properties
Safety Information
MSDS Information
STING agonist-31 Usage And Synthesis
UsesSTING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].
in vivo

STING agonist-31 (Compound 40) (10 mg/kg, i.v.) inhibits tumor growth in 4T1 and CT26 tumor mice model[1].
STING agonist-31 (1 mg/kg, i.v., rats) shows T1/2: 0.697 h, AUClast: 678 hng/mL[1].

Animal Model:Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1]
Dosage:10 mg/kg
Administration:i.v., at days 1, 4, and 7
Result:Inhibited tumor Growth.
References[1] Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669. DOI:10.1021/acs.jmedchem.0c01900
STING agonist-31 Preparation Products And Raw materials
Tag:STING agonist-31(2719001-44-0) Related Product Information
STING agonist-17 STING agonist-31 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-(3-hydroxypropoxy)-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy- 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-amino-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-, hydrochloride (1:2) 3-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-3H-imidazo[4,5-b]pyridine-6-carboxamide STING agonist-29