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| | Ozanimod Impurity 8 Basic information |
| Product Name: | Ozanimod Impurity 8 | | Synonyms: | Ozanimod Impurity 8;Glycine, N-[(1S)-4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-;(S)-1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-indene-4-carboximidamide;(S)-N-hydroxy-1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-indene-4-carboximidamide;Ozanimod Impurity 9 | | CAS: | 2990018-57-8 | | MF: | C23H22N4O4 | | MW: | 418.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2990018-57-8.mol |  |
| | Ozanimod Impurity 8 Chemical Properties |
| Boiling point | 664.8±65.0 °C(predicted) | | density | 1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 2.33±0.10(predicted) | | form | Solid | | color | Off-white to light yellow | | InChIKey | HICWSCLKDYAXPD-IBGZPJMESA-N | | SMILES | N([C@H]1CCC2C1=CC=CC=2C1=NOC(C2C=CC(=C(C=2)C#N)OC(C)C)=N1)CC(=O)O |
| | Ozanimod Impurity 8 Usage And Synthesis |
| Uses | RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely[1]. | | IC 50 | S1PR1: 0.19 nM (EC50); S1PR5: 32.8 nM (EC50) | | References | [1] Tran JQ, et al. Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clin Pharmacol Drug Dev. 2018;7(3):263-276. DOI:10.1002/cpdd.383
[2] Gilardi D, et al. PK, PD, and interactions: the new scenario with JAK inhibitors and S1P receptor modulators, two classes of small molecule drugs, in IBD [published online ahead of print, 2020 Jul 1]. Expert Rev Gastroenterol Hepatol. 2020;1-10. DOI:10.1080/17474124.2020.1785868 |
| | Ozanimod Impurity 8 Preparation Products And Raw materials |
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