- Tetraethyl ranelate
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- $1.00 / 1KG
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2026-03-20
- CAS:58194-26-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Tetraethyl ranelate
-
- $15.00/ kg
-
2024-04-22
- CAS:58194-26-6
- Min. Order: 1kg
- Purity: 99.912%
- Supply Ability: 10ton
- Tetraethyl ranelate
-
- $1.00 / 1KG
-
2019-07-06
- CAS:58194-26-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20kg
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| | Tetraethyl ranelate Basic information |
| Product Name: | Tetraethyl ranelate | | Synonyms: | 2-[N,N-di(ethoxycarbonylmethyl)amino]-3-cyano-4-ethoxycarbonylmethylthiophene-5-carboxylic acid ethyl ester;INTERMEDIATE:STRONTIUMRANELATE;TETRAETHYL RANELATE;5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(ethoxycarbonyl)-3-thiopheneacetic acid ethyl ester;Diethyl 2,2'-(3-cyano-4-(2-ethoxy-2-oxoethyl)-5-(ethoxycarbonyl)thiophen-2-ylazanediyl)diacetate;10G/50G/5KGS;Diethyl 2,2'-((3-cyano-4-(2-ethoxy-2-oxoethyl)-5-(ethoxycarbonyl)thiophen-2-yl)azanediyl)diacetat;Intermediate of Strontium ranelate | | CAS: | 58194-26-6 | | MF: | C20H26N2O8S | | MW: | 454.49 | | EINECS: | 1806241-263-5 | | Product Categories: | Strontium Ranelate | | Mol File: | 58194-26-6.mol |  |
| | Tetraethyl ranelate Chemical Properties |
| Melting point | 103-106 °C | | Boiling point | 579.2±50.0 °C(Predicted) | | density | 1.28 | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | -3.75±0.50(Predicted) | | form | Solid | | color | White to Off-White |
| | Tetraethyl ranelate Usage And Synthesis |
| Synthesis | (1) In a 20 liter autoclave, 1 kg ethyl 5-amino-4-cyano-3-(2-ethoxy-2-carboxymethyl)-2-thiophenecarboxylate, 12 liters of tetrahydrofuran, 1.92 kg potassium carbonate, 2.3 kg ethyl bromoacetate, and 20 grams of crown ether were added and heated to reflux, and the progress of the reaction was monitored by high-performance liquid chromatography (HPLC) (Fig. 9 shows the end of the reaction by HPLC). control plot), the reaction took about 3-4 hours to complete. After completion of the reaction, the mixture was filtered and the filtrate was concentrated by distillation under reduced pressure. Subsequently, 4 liters of ethanol were added and pulped under ice bath conditions for 3-4 hours and filtered again. The filter cake was washed with ice ethanol and finally dried in an oven at 45°C to obtain 1.25 kg of ethyl 5-[bis(2-ethoxy-2-carboxymethyl)amino-]-4-cyano-3-(2-ethoxy-2-carboxymethyl)-2-thiophene carboxylate in 91% yield and 99.86% purity. | | References | [1] Patent: CN103804345, 2017, B. Location in patent: Paragraph 0044; 0047; 0050
[2] Heteroatom Chemistry, 2007, vol. 18, # 3, p. 236 - 238
[3] Patent: WO2011/124992, 2011, A1. Location in patent: Page/Page column 19-20 |
| | Tetraethyl ranelate Preparation Products And Raw materials |
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