1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-

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1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- Basic information
Product Name:1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-
Synonyms:1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-;(R)-GSK866
CAS:1094607-80-3
MF:C23H21Cl2F4N5O3
MW:562.34
EINECS:
Product Categories:
Mol File:1094607-80-3.mol
1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- Structure
1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- Chemical Properties
Boiling point 761.3±60.0 °C(predicted)
density 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.13±0.46(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- Usage And Synthesis
Uses(R)-GSK866 is the (R)-enantiomer of GSK866 (HY-157294). GSK866 is a selective agonist for glucocorticoid receptor with an IC50 of 4.6 nM[1].
References[1] Chandra S Chirumamilla, et al. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Front Immunol. 2017 Nov 1:8:1324. DOI:10.3389/fimmu.2017.01324
1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)- Preparation Products And Raw materials
Tag:1H-Pyrazole-4-carboxamide, 5-amino-N-[(2R)-2-[[(2,6-dichlorobenzoyl)ethylamino]methyl]-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-(1094607-80-3) Related Product Information
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