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| | 6-(1H-Pyrazol-1-yl)nicotinic acid Basic information |
| Product Name: | 6-(1H-Pyrazol-1-yl)nicotinic acid | | Synonyms: | 6-(1H-Pyrazol-1-yl)nicotinic acid ,97%;6-(1H-Pyrazol-1-yl)pyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)nicotinic acid;6-pyrazol-1-ylpyridine-3-carboxylic acid;6-Pyrazol-1-yl-nicotinic acid;3-Pyridinecarboxylic acid, 6-(1H-pyrazol-1-yl)-;6-(1-Pyrazolyl)nicotinic Acid;CAS:253315-22-9 | | CAS: | 253315-22-9 | | MF: | C9H7N3O2 | | MW: | 189.17 | | EINECS: | | | Product Categories: | | | Mol File: | 253315-22-9.mol |  |
| | 6-(1H-Pyrazol-1-yl)nicotinic acid Chemical Properties |
| Melting point | 272-274℃ | | Boiling point | 394.6±27.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | 3.28±0.10(Predicted) | | color | White to off-white | | CAS DataBase Reference | 253315-22-9 |
| | 6-(1H-Pyrazol-1-yl)nicotinic acid Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 6-(1H-Pyrazol-1-yl)nicotinic acid is used as a ligand in the synthesis of MOF materials. | | Synthesis | Compound 1 (CAS: 1428929-49-0, 8.66 g, 40.43 mmol, 1.0 eq.) was dissolved in anhydrous ethanol (80 mL), followed by slow addition of 3 M aqueous sodium hydroxide solution (40.40 mL, 121.3 mmol, 3.0 eq.). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by reduced pressure distillation and the residue was dissolved in deionized water (60 mL). The aqueous phase was extracted twice with ether (40 mL × 2) to remove organic impurities. Subsequently, the pH of the aqueous phase was adjusted to 3 with 2 M aqueous hydrochloric acid, at which time a white solid precipitated. The white solid was collected by filtration and dried to give 6-(1H-pyrazol-1-yl)nicotinic acid (7.42 g, 97% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 6.65 (dd, J = 2.7, 1.6 Hz, 1H, Ar-H), 7.92 (dd, J = 1.6, 0.8 Hz, 1H, Ar-H), 8.04 (dd, J = 8.6, 0.8 Hz, 1H, Ar-H), 8.44 (dd, J = 8.6 , 2.3 Hz, 1H, Ar-H), 8.70 (dd, J = 2.7, 0.8 Hz, 1H, Ar-H), 8.96 (dd, J = 2.3, 0.8 Hz, 1H, Ar-H), 13.44 (s, 1H, COOH). | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 68 - 90
[2] Patent: WO2014/85210, 2014, A1. Location in patent: Page/Page column 40 |
| | 6-(1H-Pyrazol-1-yl)nicotinic acid Preparation Products And Raw materials |
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