SMARCA2-IN-7

Request For Quotation
SMARCA2-IN-7 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:SMARCA2-IN-7
CAS:2270879-43-9
Package:50mg;10mg
SMARCA2-IN-7 Basic information
Product Name:SMARCA2-IN-7
Synonyms:SMARCA2-IN-7;Urea, N-[2-chloro-5-(hydroxymethyl)-4-pyridinyl]-N′-[3-(difluoromethyl)-5-isothiazolyl]-
CAS:2270879-43-9
MF:
MW:334.73
EINECS:
Product Categories:
Mol File:2270879-43-9.mol
SMARCA2-IN-7 Structure
SMARCA2-IN-7 Chemical Properties
Boiling point 354.975±42.00 °C(Press: 760.00 Torr)(predicted)
density 1.678±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka11.877±0.70(predicted)
Safety Information
MSDS Information
SMARCA2-IN-7 Usage And Synthesis
UsesSMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM[1].
References[1] Papillon JPN,et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Medicinal Chemistry. 2018 Nov 21;61(22):10155-10172. DOI:10.1021/acs.jmedchem.8b01318
SMARCA2-IN-7 Preparation Products And Raw materials
Tag:SMARCA2-IN-7(2270879-43-9) Related Product Information