7-Bromo-1-benzofuran-2-carboxylicacid

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7-Bromo-1-benzofuran-2-carboxylicacid Basic information
Application
Product Name:7-Bromo-1-benzofuran-2-carboxylicacid
Synonyms:7-Bromo-2-benzofurancarboxylic acid;2-Benzofurancarboxylic acid, 7-bromo-;7-Bromo-1-benzofuran-2-carboxylicacid
CAS:550998-59-9
MF:C9H5BrO3
MW:241.04
EINECS:
Product Categories:
Mol File:550998-59-9.mol
7-Bromo-1-benzofuran-2-carboxylicacid Structure
7-Bromo-1-benzofuran-2-carboxylicacid Chemical Properties
Boiling point 370.9±22.0 °C(Predicted)
density 1.784±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka2.90±0.30(Predicted)
AppearanceOff-white to light yellow Solid
CAS DataBase Reference550998-59-9
Safety Information
HS Code 2933399990
MSDS Information
7-Bromo-1-benzofuran-2-carboxylicacid Usage And Synthesis
Application7-Bromobenzofuran-2-carboxylic acid can be used as a pharmaceutical synthesis intermediate.
SynthesisMethod 1, two-step synthesis. 1) Preparation of 3-bromo-2-hydroxybenzaldehyde: 2-Bromophenol is heated under reflux with anhydrous magnesium chloride, paraformaldehyde, and triethylamine in acetonitrile. Work-up yields the product. 2) Preparation of 7-bromobenzofuran-2-carboxylic acid: The product from step 1 (crude) is heated with methyl chloroacetate, tetra-n-butylammonium iodide, and potassium carbonate. Water and THF are then added, followed by potassium hydroxide, and the mixture is stirred at room temperature overnight. Subsequent acidification and extraction/purification yield the product.
7-Bromo-1-benzofuran-2-carboxylicacid Preparation Products And Raw materials
Tag:7-Bromo-1-benzofuran-2-carboxylicacid(550998-59-9) Related Product Information
7-Bromo-benzo[b]thiophene Benzofuran Dibenzofuran 7-Bromobenzo[d]isoxazol-3-amine 7-BroMobenzo[d]oxazol-2-aMine 7-BroMobenzo[d]isoxazole 7-BroMo-benzothiazole-2-carboxylic acid 7-Bromobenzo[b]furan 7-Bromobenzo[d]oxazole 7-bromobenzo[b]thiophene-2-carbaldehyde Benzo[b]thiophene-2-carboxylic acid, 7-bromo- 7-bromobenzo[d]thiazole-2-thiol Ethyl 7-bromobenzofuran-2-carboxylate 3-Bromo-2-methoxy-5-trifluoromethylpyridine 7-Bromo-1-benzofuran-2-carboxylicacid 5,7-Dibromo-benzofuran-2-carboxylic acid 2-Benzofurancarboxylic acid, 7-bromo-5-nitro-, ethyl ester CHEMBRDG-BB 6725612