4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE manufacturers
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| | 4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Basic information |
| Product Name: | 4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE | | Synonyms: | 2-Carboxy-5-oxo-5,6,7,8-tetrahydronaphthalene;6-Carboxy-1-oxo-1,2,3,4-tetrahydronaphthalene, 5-Oxo-5,6,7,8-tetrahydro-2-naphthoic acid;4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE;4-[(4-METHYLPHENYL)SULPHONYL]PIPERIDINE HYDROCHLORIDE;5-Oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid 96%;5-Oxo-7,8-dihydro-6H-naphthalene-2-carboxylic Acid;2-Naphthalenecarboxylic acid, 5,6,7,8-tetrahydro-5-oxo- | | CAS: | 3470-46-0 | | MF: | C11H10O3 | | MW: | 190.2 | | EINECS: | | | Product Categories: | Benzocycles | | Mol File: | 3470-46-0.mol | ![4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Structure](CAS/GIF/3470-46-0.gif) |
| | 4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Chemical Properties |
| Melting point | 230(dec.) | | Boiling point | 230 °C/dec) | | density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.77±0.20(Predicted) | | form | solid | | color | Light brown |
| Hazard Codes | Xi,C | | HazardClass | IRRITANT | | HS Code | 2902900000 |
| | 4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Usage And Synthesis |
| Synthesis | Methyl 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate (320 mg, 1.57 mmol) was used as a raw material and dissolved in a solvent mixture of 6 mL of methanol and 3 mL of water. Subsequently, lithium hydroxide (331 mg, 7.88 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. The progress of the reaction was monitored by thin-layer chromatography (TLC), and after confirming that the reaction was complete, the pH of the reaction solution was adjusted to 5 with 1 N hydrochloric acid solution.The reaction solution was concentrated by rotary evaporation and extracted with ethyl acetate (50 mL × 2). The ethyl acetate extracts were combined and the solvent was removed by rotary evaporation to afford the white solid product 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (310 mg, 100% yield). | | References | [1] Patent: CN104844471, 2017, B. Location in patent: Paragraph 0186; 0187; 0188 |
| | 4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Preparation Products And Raw materials |
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