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| | 6-bromoimidazo[1,2-a]pyrazin-8-amine Basic information |
| Product Name: | 6-bromoimidazo[1,2-a]pyrazin-8-amine | | Synonyms: | 6-bromo-8-imidazo[1,2-a]pyrazinamine;6-bromoimidazo[1,2-a]pyrazin-8-amine;8-Amino-6-bromoimidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazin-8-amine,6-bromo-;2-a]pyrazin-8-aMine;8-bromoimidazo[1,2-a]pyrazin-6-amine;6-Bromo-8-aminoimidazo[1,2-a]pyrazine;PAB 12 | | CAS: | 117718-84-0 | | MF: | C6H5BrN4 | | MW: | 213.03 | | EINECS: | | | Product Categories: | CHIRAL CHEMICALS | | Mol File: | 117718-84-0.mol | ![6-bromoimidazo[1,2-a]pyrazin-8-amine Structure](CAS/GIF/117718-84-0.gif) |
| | 6-bromoimidazo[1,2-a]pyrazin-8-amine Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Appearance | Yellow to brown Solid |
| | 6-bromoimidazo[1,2-a]pyrazin-8-amine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 6-bromoimidazo[1,2-A]pyrazin-8-amine from 6,8-dibromo-imidazo[1,2-A]pyrazine: The product obtained from the preparation of Example 29 (1.80 g, 6.45 mmol) was mixed with concentrated aqueous NH4OH solution (27.0 mL) in a closed pressure vessel and reacted with stirring for 24 hrs at 90 °C. Upon completion of the reaction, the solvent was removed by evaporation and the resulting residue was purified by silica gel column chromatography with EtOAc as eluent. A white solid product (1.01 g, 73% yield) was finally obtained.LCMS analysis showed that MH+ = 213. | | References | [1] Journal of Medicinal Chemistry, 1992, vol. 35, # 18, p. 3353 - 3358
[2] Patent: US2004/63715, 2004, A1. Location in patent: Page/Page column 27
[3] Patent: WO2004/22562, 2004, A1. Location in patent: Page 28 |
| | 6-bromoimidazo[1,2-a]pyrazin-8-amine Preparation Products And Raw materials |
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