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| | mTOR Rabbit Monoclonal Antibody (Clone RM274) Basic information |
| | mTOR Rabbit Monoclonal Antibody (Clone RM274) Chemical Properties |
| | mTOR Rabbit Monoclonal Antibody (Clone RM274) Usage And Synthesis |
| Description | Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and member of the PI3K-related kinase family with roles in the regulation of cell growth and metabolism.1,2 It is comprised of N-terminal tandemly repeated HEAT motifs that facilitate protein-protein interactions, a FRAP, ATM, and TRRAP (FAT) domain, an FKBP12-rapamycin binding (FRB) domain, a catalytic kinase domain, an autoinhibitory/repressor domain, and a FAT carboxy-terminal (FATC) domain that is essential to kinase activity.2 mTOR is ubiquitously expressed in the cytosol and is the catalytic subunit of mTOR complex 1 (mTORC1) and mTORC2, which have roles in aging, autophagy, stem cell and immune function, cellular senescence, and macromolecule biogenesis, and cell survival, cytoskeletal organization, and metabolism, respectively.2,3 It is a component of the PI3K/AKT/mTOR signaling pathway that acts as a junction point both upstream and downstream of AKT.4 Dysregulation of the mTOR signaling pathway is associated with various pathologies, including cancer, rheumatoid arthritis, epilepsy, neurodegenerative diseases, and diabetes.4,5,2 Cayman’s mTOR Rabbit Monoclonal Antibody (Clone RM274) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | mTOR Rabbit Monoclonal Antibody (Clone RM274) Preparation Products And Raw materials |
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