- Colistin
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2026-11-06
- CAS:1066-17-7
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 1000kg
- colistin
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- $100.00
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2026-11-05
- CAS:1066-17-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000 KG
- amoxicillin
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- $10.00
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2026-03-20
- CAS:1066-17-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10 mt
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| Product Name: | COLISTIN | | Synonyms: | COLISTIN;colimycin;Aids033059;Aids-033059;Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin;PolyMyxin E coMplex;[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(1S,4S,7R,10S,13S,16S,19S)-4,13,16-tris(2-aminoethyl)-19-[(1R)-1-hydroxyethyl]-10-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-7-(phenylmethyl)-3,6;Polyoxin W.P. | | CAS: | 1066-17-7 | | MF: | C52H98N16O13 | | MW: | 1155.43 | | EINECS: | 213-907-3 | | Product Categories: | | | Mol File: | 1066-17-7.mol |  |
| | COLISTIN Chemical Properties |
| Boiling point | 807.67°C (rough estimate) | | density | 1.1050 (rough estimate) | | refractive index | 1.6700 (estimate) | | storage temp. | Store at -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | CAS DataBase Reference | 1066-17-7 |
| RIDADR | 3249 | | HazardClass | 6.1(b) | | PackingGroup | III | | Hazardous Substances Data | 1066-17-7(Hazardous Substances Data) | | Toxicity | cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960. |
| | COLISTIN Usage And Synthesis |
| Neurotoxicity and Nephrotoxicity | Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
| | Chemical Properties | White crystalline powder. Soluble in water, slightly soluble in ethanol or methanol, insoluble in acetone or ether. Hygroscopic, odorless, bitter. | | Uses | Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect. | | Brand name | Coly-Mycin (Monarch). | | in vivo | Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1]. | Animal Model: | C57/BL6 mice[1] | | Dosage: | 16 mg/kg/day | | Administration: | 16 mg/kg/day, i.p. | | Result: | Detected apoptosis, necrosis PCNA staining in mice. |
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| | COLISTIN Preparation Products And Raw materials |
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