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| | Histone H2AXK9Ac Rabbit Monoclonal Antibody (Clone RM446) Basic information |
| | Histone H2AXK9Ac Rabbit Monoclonal Antibody (Clone RM446) Chemical Properties |
| | Histone H2AXK9Ac Rabbit Monoclonal Antibody (Clone RM446) Usage And Synthesis |
| Description | Histone H2AX is a variant of histone H2A, a nuclear protein and a component of the nucleosome core.1,2 It is a globular protein containing unstructured N- and C-terminal tails that extend outside of the nucleosome core that are subject to a variety of post-translational modifications (PTMs), including phosphorylation, acetylation, methylation, and ubiquitination, which function as epigenetic regulators of transcription.3,4 H2AX has a key role in the DNA damage response.3,4,1,5 It is phosphorylated at serine 139 (γH2AX) by the PI3K-like kinases ataxia-telangiectasia mutated kinase (ATM) and ataxia-telangiectasia, Rad3-related protein/kinase (ATR), and DNA protein kinase (DNA-PK) in response to DNA damage, leading to changes in chromatin structure at the damaged site that promote DNA repair. H2AX has additional roles in chromatin inactivation during meiosis and mitosis, as well as neural stem cell development and cellular senescence.5 Decreased tumor levels of H2AX are associated with increased progression-free survival in patients with triple-negative breast cancer.6 Tumor levels of acetylated lysine 9 on histone H2AX (H2AXK9Ac) are increased in patients with oligodendrogliomas.7 Cayman’s Histone H2AXK9Ac Rabbit Monoclonal Antibody (Clone RM446) can be used for multiplex-based assay and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | Histone H2AXK9Ac Rabbit Monoclonal Antibody (Clone RM446) Preparation Products And Raw materials |
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