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| | Histone H2BK5Ac Rabbit Monoclonal Antibody (Clone RM455) Basic information |
| | Histone H2BK5Ac Rabbit Monoclonal Antibody (Clone RM455) Chemical Properties |
| | Histone H2BK5Ac Rabbit Monoclonal Antibody (Clone RM455) Usage And Synthesis |
| Description | Histone H2B is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains a histone fold domain with a C-terminal α-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation.1,2,3 Acetylation of histone H2B at lysine 5 (H2BK5Ac) promotes the expression of genes associated with maintenance of the epithelial phenotype in trophoblast stem cells and stem-like claudin-low breast cancer cells.4 Histone H2BK5Ac is enriched at cardiac and renal promotors in diabetic rats.5 Cayman’s Histone H2BK5Ac Rabbit Monoclonal Antibody (Clone RM455) can be used for ELISA, multiplex-based assay, and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | Histone H2BK5Ac Rabbit Monoclonal Antibody (Clone RM455) Preparation Products And Raw materials |
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