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| | METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Basic information |
| Product Name: | METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE | | Synonyms: | METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE;Tenoxicam Impurity 1;Albb-008913;methy1 4-hydroxy-2H-thieno[2,3 -e]-1,2-thiazine-3-carboxylate-1, 1-dioxide;methyl 4-hydroxy-1,1-dioxo-2H-thieno[2,3-e]thiazine-3-carboxylate;Methyl 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate...;Tenoxicam Impurity 7;2H-Thieno[2,3-e]-1,2-thiazine-3-carboxylic acid, 4-hydroxy-, methyl ester, 1,1-dioxide | | CAS: | 98827-44-2 | | MF: | C8H7NO5S2 | | MW: | 261.27 | | EINECS: | 619-376-8 | | Product Categories: | | | Mol File: | 98827-44-2.mol | ![METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Structure](CAS/GIF/98827-44-2.gif) |
| | METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Chemical Properties |
| Boiling point | 464.2±55.0 °C(Predicted) | | density | 1.716 | | pka | 4.50±1.00(Predicted) |
| | METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1-dioxide from methyl 3-sulfonamidoacetate-2-thiophenecarboxylate: 8.5 g of methyl 3-sulfonamidoacetate-2-thiophenecarboxylic acid methyl ester (TNXK-1), 27.2 g of a 7% sodium methanol solution, and 15 mL of anhydrous methanol were mixed. The reaction was heated to reflux with stirring and maintained for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 200 mL of water. Subsequently, the reaction mixture was neutralized with 10% hydrochloric acid solution to pH 3. After neutralization, the solvent was removed by evaporation, the residue was cooled, and the pH was adjusted again with 10% hydrochloric acid to 3. The precipitate was collected by filtration, and the filter cake was washed with water and dried to give 5.6 g of the yellowish-green solid product, 4-hydroxy-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methyl ester-1,1 -dioxide (TNXK-2) The yield was 79%. | | References | [1] Patent: CN107141308, 2017, A. Location in patent: Paragraph 0046-0050; 0064; 0068; 0074; 0078; 0084; 0088
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 4, p. 678 - 682 |
| | METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE Preparation Products And Raw materials |
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