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| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- Basic information |
| Product Name: | 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- | | Synonyms: | 5-Bromo-7-azaindole-3-carboxaldehyde;5-BroMo-3-forMyl-7-azaindole;5-bromo-5,6-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde;1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo-;5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde;5-Bromo-1H-pyrrolo pyridine-3-carbaldehyde;5-Bromo-7-azaindole-3-carbaldehyde;5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehydealdehyde | | CAS: | 757978-33-9 | | MF: | C8H5BrN2O | | MW: | 225.04 | | EINECS: | | | Product Categories: | Heterocycle-Pyridine series | | Mol File: | 757978-33-9.mol | ![1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- Structure](CAS/GIF/757978-33-9.gif) |
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- Chemical Properties |
| density | 1.830±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 11.42±0.40(Predicted) | | Appearance | White to off-white Solid |
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- Usage And Synthesis |
| Synthesis | (a) Step 1: Glacial acetic acid (0.2 mL), water (0.4 mL) and hexamethylenetetetramine (0.087 g, 0.62 mmol) were added sequentially to 5-bromo-7-azaindole (0.087 g, 0.44 mmol), and the reaction was carried out in a sealed tube with stirring at 120°C overnight. Upon completion of the reaction, water was added to the mixture and the precipitated solid was collected by filtration to afford 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (0.061 g, 62% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.46 (d, J = 2.2 Hz, 1H), 8.53 (d, J = 2.2 Hz, 1H), 8.54 (s, 1H), 9.93 (s, 1H). | | References | [1] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0304
[2] Patent: US2015/259357, 2015, A1. Location in patent: Paragraph 1561 |
| | 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- Preparation Products And Raw materials |
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