- ICI 63197
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- $77.00 / 100mg
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2025-12-31
- CAS:27277-00-5
- Min. Order:
- Purity: 99.70%
- Supply Ability: 10g
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| | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Basic information |
| Product Name: | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one | | Synonyms: | 2-AMINO-6-METHYL-4-PROPYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-5(4H)-ONE;2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4] TRIAZOLE-[1,5-A] PYRIMIDINE-5-ONE;2-AMINO-6-METHYL-4-PROPYL-4H-[1,2,4]TRIAZOLO-[1,5-A]PYRIMIDIN-5-ONE;2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-A]PYRIMIDINE;ICI 63197;2,4]triazolo[1,5-a]pyrimidin-5(4h)-one,2-amino-6-methyl-4-propyl-[;2-Amio-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one;2-AMINO-6-METHYL-5-OXO-4-N-PROPYL-4,5-DIHYDRO-S-TRIAZOLE[1,5-α]PYRIMIDIN | | CAS: | 27277-00-5 | | MF: | C9H13N5O | | MW: | 207.23 | | EINECS: | 248-383-5 | | Product Categories: | Cyclic Nucleotide related | | Mol File: | 27277-00-5.mol | ![2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Structure](CAS/GIF/27277-00-5.gif) |
| | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Chemical Properties |
| RIDADR | 2811 | | WGK Germany | 1 | | TSCA | TSCA listed | | HazardClass | 6.1(b) | | PackingGroup | III |
| | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Usage And Synthesis |
| Uses | ICI 63197 is a specific cAMP phosphodiesterase (PDE) inhibitor. It is potent in anatagonizing reserpine-induced hypothermia. potent PDE4 inhibitor. | | Definition | ChEBI: 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one is a member of triazolopyrimidines. | | Flammability and Explosibility | Not classified | | Biological Activity | Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo . | | Biochem/physiol Actions | Phosphodiesterase IV (PDE 4) inhibitor | | Synthesis | 2-Amino-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one (165 g, 1 mol) and bromopropane (184 g, 1.5 mol) were added to the reaction apparatus, followed by triethylamine (101 g, 1 mol) and chloroform (900 mL). The reaction mixture was heated to 65 °C and maintained at this temperature for 6 hours. The progress of the reaction was monitored by HPLC until the amount of 2-amino-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one was less than 0.5%. After completion of the reaction, the chloroform was recovered by distillation at 50 °C. Ethyl acetate (830 mL) and water (330 mL) were added to the residue and the organic phase was separated by stirring. After distillation to remove some of the ethyl acetate (~500mL), the remaining solution was crystallized. The crystals were collected by filtration and washed with water until the wash solution was neutral. Finally, dried to constant weight at 70 °C to afford 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one (176 g, 85% yield, 99% purity). | | storage | +4°C | | References | [1] Patent: CN107602563, 2018, A. Location in patent: Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034-0044 |
| | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Preparation Products And Raw materials |
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