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| | 4-(2-Methoxyethylamino)piperidine-1-carboxylic acid tert-butyl ester Basic information |
| Product Name: | 4-(2-Methoxyethylamino)piperidine-1-carboxylic acid tert-butyl ester | | Synonyms: | 4-(2-METHOXYETHYLAMINO)PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;TERT-BUTYL 4-[(2-METHOXYETHYL)AMINO]PIPERIDINE-1-CARBOXYLATE;4-(2-methoxyethylamino)piperidine-1-carbpxylic acid tert-butyl ester;1-Boc-4-(2-methoxyethylamino)piperidine;1,1-diMethylethyl 4-([2-(Methyloxy)ethyl]aMino)-1-piperidinecarboxylate;4-(2-methoxyethylamino)-1-piperidinecarboxylic acid tert-butyl ester;1-Boc-N-(2-methoxyethyl)piperidin-4-amine;N-Boc-4-(2-methoxyethylamino)-piperidine | | CAS: | 710972-40-0 | | MF: | C13H26N2O3 | | MW: | 258.36 | | EINECS: | | | Product Categories: | | | Mol File: | 710972-40-0.mol |  |
| | 4-(2-Methoxyethylamino)piperidine-1-carboxylic acid tert-butyl ester Chemical Properties |
| Boiling point | 337.6±32.0 °C(Predicted) | | density | 1.03±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 9.01±0.20(Predicted) | | Appearance | Colorless to light yellow Liquid |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | 4-(2-Methoxyethylamino)piperidine-1-carboxylic acid tert-butyl ester Usage And Synthesis |
| Synthesis | To a solution of N-tert-butoxycarbonyl-4-piperidone (1 g, 5.0 mmol) in methanol (20 mL) was sequentially added acetic acid (0.3 mL, 5.0 mmol), 2-methoxyethylamine (0.44 mL, 5.0 mmol), and sodium cyanoborohydride (346 mg, 5.5 mmol). The reaction mixture was stirred at 25°C for 12 hours. After completion of the reaction, the reaction solution was diluted with aqueous sodium carbonate and extracted with ethyl acetate several times. The organic phases were combined, concentrated and purified by silica gel column chromatography (eluent: dichloromethane/methanol, 0-10% gradient) to afford tert-butyl 4-(2-methoxyethylamino)piperidine-1-carboxylate (1.2 g, 93%) as a yellow oil.LC/MS (ES) m/e 259 (M+H)+. | | References | [1] Patent: WO2007/16610, 2007, A2. Location in patent: Page/Page column 49; 50
[2] Patent: WO2017/21730, 2017, A1. Location in patent: Page/Page column 59
[3] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 56; 58
[4] Patent: CN107814792, 2018, A. Location in patent: Paragraph 0223; 0224
[5] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 94-95; 101-102 |
| | 4-(2-Methoxyethylamino)piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials |
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