| Company Name: |
BOC Sciences |
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16314854226 |
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info@bocsci.com |
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| | KF31327 Basic information |
| Product Name: | KF31327 | | Synonyms: | KF31327;3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione;Thioquinapiperifil;2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]-;KF-31327 free base;Thioquinapiperifil (Standard);Thioquinapiperfil | | CAS: | 220060-39-9 | | MF: | C24H28N6OS | | MW: | 448.59 | | EINECS: | | | Product Categories: | | | Mol File: | 220060-39-9.mol |  |
| | KF31327 Chemical Properties |
| Boiling point | 676.558±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.384±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 10.425±0.30(predicted) |
| | KF31327 Usage And Synthesis |
| Uses | Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2]. | | Biological Activity | Thioquinapiperifil (KF31327 free base) is a potent, selective, and noncompetitive inhibitor of phosphodiesterase (PDE-5) (IC50 of 0.074 nM) for sexual maturation studies. | | in vitro | Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation. | | target | | PDE5 0.074 nM (IC 50 ) | PDE1 380 nM (IC 50 ) | PDE2 670 nM (IC 50 ) | PDE3 38 nM ( IC 50 ) | PDE4 800 nM (IC 50 ) | | | IC 50 | PDE5: 0.074 nM (IC50); PDE1: 380 nM (IC50); PDE2: 670 nM (IC50); PDE3: 38 nM (IC50); PDE4: 800 nM (IC50) | | References | [1] Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. DOI:10.1248/cpb.56.1331
[2] R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. DOI:10.1016/s0014-2999(01)01422-4 |
| | KF31327 Preparation Products And Raw materials |
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