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| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Basic information |
| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Chemical Properties |
| Melting point | 193-193.5℃ | | Boiling point | 473.2±45.0 °C(Predicted) | | density | 1.424±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.19±0.20(Predicted) | | form | A powder | | color | White to off-white |
| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Usage And Synthesis |
| Description | Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 μM). It also inhibits DNA topoisomerase I when used at a concentration of 45 μM in B16F10 melanoma cells. Reticulol has antifungal activity against T. mentagrophyes with a MIC of 1.8 μM. It is cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 μM, respectively, and inhibits lung metastasis in mice. | | Uses | Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model. | | Uses | Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I. | | in vivo | Reticulol (10 mg/kg, 50 mg/kg; iv; day 3 and day 5 after tumor implanted) inhibits tumor growth in mice bearing B16F10 melanoma, and shows lung metastasis-blocking effect[1]. | Animal Model: | Pathogen-free female C57BL/6J mice[1] | | Dosage: | 10 mg/kg, 50 mg/kg | | Administration: | IV via the tail vein; day 3 and day 5 after tumor implanted | | Result: | Inhibited tumor growth.
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| | storage | +4°C | | References | [1] L A MITSCHER W M W W Andres. Reticulol, a new metabolic isocoumarin.[J]. Experientia, 1964, 20 5: 258-259. DOI: 10.1007/bf02151790
[2] Y FURUTANI. Reticulol, an inhibitor of cyclic adenosine 3’, 5’-monophosphate phosphodiesterase.[J]. Journal of Antibiotics, 1975, 28 7: 558-560. DOI: 10.7164/antibiotics.28.558
[3] DAE-SEOG LIM. Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma.[J]. Chemotherapy, 2003, 49 5: 257-263. DOI: 10.1159/000072451
[4] DAE-SEOG LIM. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma.[J]. Chemotherapy, 2003, 49 3: 146-153. DOI: 10.1159/000070621 |
| | 6,8-Dihydroxy-7-methoxy-3-methyl-1H-2-benzopyran-1-one Preparation Products And Raw materials |
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