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| | 4-Aminoisophthalic acid Basic information |
| Product Name: | 4-Aminoisophthalic acid | | Synonyms: | 4-Aminoisophthalic acid;4-Amino-1,3-benzenedicarboxylic acid;5-Carboxyanthranilic acid;-Aminoisophthalic acid;1,3-Benzenedicarboxylic acid, 4-amino-;4-aminobenzene-1,3-dicarboxylicaci;tert-butyl 2-(4-Methoxybenzyl)-3-oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylate;4-aminometabenzenedimacetic acid | | CAS: | 33890-03-8 | | MF: | C8H7NO4 | | MW: | 181.15 | | EINECS: | | | Product Categories: | | | Mol File: | 33890-03-8.mol |  |
| | 4-Aminoisophthalic acid Chemical Properties |
| Melting point | 336-337℃ | | Boiling point | 458.1±40.0 °C(Predicted) | | density | 1.551 | | storage temp. | RT, protect from light | | pka | 4.49±0.10(Predicted) | | Appearance | Off-white to brown Solid |
| | 4-Aminoisophthalic acid Usage And Synthesis |
| Chemical Properties | Off-white powder | | Synthesis | General procedure: 4-nitroisophthalic acid (98 g, 0.457 mol) was dissolved in methanol (5 L) and 20% Pd/C catalyst was added. The hydrogenation reaction was carried out at room temperature for 4 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated in vacuum to afford 4-aminoisophthalic acid (72 g, 87% yield) as a white solid. The product was detected by thin layer chromatography (TLC) with chloroform/methanol (7:3) as the unfolding agent and an Rf value of 0.4. | | References | [1] Patent: WO2005/11686, 2005, A1. Location in patent: Page 38
[2] Patent: WO2004/7491, 2004, A1. Location in patent: Page 57
[3] Farmaco, Edizione Scientifica, 1984, vol. 39, # 11, p. 968 - 978
[4] Patent: US2008/280900, 2008, A1
[5] Patent: US6635657, 2003, B1 |
| | 4-Aminoisophthalic acid Preparation Products And Raw materials |
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