ONO-3307 manufacturers
- Ono-3307 mesylate
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- $293.00
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2026-06-15
- CAS:76472-29-2
- Purity: 99.85%
- Supply Ability: 10g
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| | ONO-3307 Basic information |
| Product Name: | ONO-3307 | | Synonyms: | Ono-3307 mesylate;Ono 3307 mesylate,Ono3307 mesylate | | CAS: | 76472-29-2 | | MF: | C14H14N4O4S | | MW: | 334.35036 | | EINECS: | | | Product Categories: | | | Mol File: | 76472-29-2.mol |  |
| | ONO-3307 Chemical Properties |
| | ONO-3307 Usage And Synthesis |
| Description | Ono-3307 is a protease inhibitor potentially for the treatment of thrombosis. ONO-3307 competitively inhibited trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein and chymotrypsin; and their Ki values were 0.048 microM, 0.18 microM, 0.29 microM, 0.31 microM, 3.6 microM and 47 microM, respectively. In addition, ONO-3307 inhibited both elastase release from N-formyl-Met-Leu-Phe (fMLP)-stimulated leukocytes and tissue thromboplastin release from endotoxin-stimulated leukocytes. ONO-3307 exhibits a wide range of inhibitory effects on various proteases, and ONO-3307 may be useful for the treatment of protease-mediated diseases such as thrombosis and DIC. | | Uses | ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases[1][2]. | | References | [1] Yoshikawa T, et al. Protective effects of ONO-3307, a new synthetic protease inhibitor against experimental disseminated intravascular coagulation in rats. Thromb Res. 1990 Oct 1;60(1):1-7. DOI:10.1016/0049-3848(90)90334-9
[2] Matsuoka S, et al. Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51(4):455-63. DOI:10.1254/jjp.51.455 |
| | ONO-3307 Preparation Products And Raw materials |
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