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| | CALCIUM TITRIPLEX(R), DIHYDRATE Basic information |
| Product Name: | CALCIUM TITRIPLEX(R), DIHYDRATE | | Synonyms: | Calciumtitriplexdihydrate;PhEur,BP,USP;Calcium disodium edta dihydrate;ETHYLENDIAMINTETRAACETIC CALCIUM DISODIU;Ca(Ⅱ)-EDTA disodium dihydrate | | CAS: | 6766-87-6 | | MF: | C10H16CaN2Na2O10 | | MW: | 410.3 | | EINECS: | | | Product Categories: | | | Mol File: | 6766-87-6.mol |  |
| | CALCIUM TITRIPLEX(R), DIHYDRATE Chemical Properties |
| solubility | Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| | CALCIUM TITRIPLEX(R), DIHYDRATE Usage And Synthesis |
| Uses | CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis[1]. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning[2][3]. | | in vivo | CaⅡ-EDTA disodium dehydrate (50 mg/kg, p.o. for 4 weeks) alleviates the toxic effects of cadmium on kidney and bone with preference to the nanoparticles form[2]. | Animal Model: | Sprague Dawley rats [2] | | Dosage: | 50 mg/kg/day | | Administration: | p.o. for 4 weeks (three-day break after each four consecutive days of administration) | | Result: | Increased the body weight compared to the Cd-intoxicated group.
Decreased in serum creatinine and cadmium concentration compared to the Cd-intoxicated group.
Showed a good radio-density of the skeleton.
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| | References | [1] Miura, T. et al., Ca (II)-EDTA shows antimicrobial activity against periodontopathic bacteria. Journal of Biomedical Science and Engineering, 5, 10-14.
[2] Saleh SM, et al., Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats Biol Trace Elem Res. 2023 Sep 18. DOI:10.1007/s12011-023-03842-6
[3] Saxena G, et al., Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18(4):221-33. DOI:10.1002/jbt.20027 |
| | CALCIUM TITRIPLEX(R), DIHYDRATE Preparation Products And Raw materials |
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