|
|
| | 4-Phenyl-4H-1,2,4-triazole Basic information |
| Product Name: | 4-Phenyl-4H-1,2,4-triazole | | Synonyms: | 4-phenyl-1,2,4-triazol-4-yl)phenol;4-Phenyl-4H-1,2,4-triazole;1H-1,2,4-Triazole, 4-phenyl-;4-Phenyl-1H-1,2,4-triazole;Brn 0115833;4H-1,2,4-Triazole, 4-phenyl-;1-Phenyl-1,3,4-triazole;4-Phenyl-1,2,4-triazole | | CAS: | 16227-12-6 | | MF: | C8H7N3 | | MW: | 145.16 | | EINECS: | | | Product Categories: | | | Mol File: | 16227-12-6.mol |  |
| | 4-Phenyl-4H-1,2,4-triazole Chemical Properties |
| Melting point | 122 °C | | Boiling point | 292℃ | | density | 1.16 | | Fp | 131℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.52±0.10(Predicted) | | Appearance | Off-white to light yellow Solid |
| | 4-Phenyl-4H-1,2,4-triazole Usage And Synthesis |
| Synthesis | General method: iodobenzene (1.2 mmol), 1,2,4-triazole (1.0 mmol), cesium carbonate (2 mmol) and Cu(OAc)2-H2O (0.01 mmol) were dissolved in N,N-dimethylformamide (2 mL) under nitrogen protection. The reaction mixture was stirred at 110 °C for 24 hours. After completion of the reaction, it was cooled to room temperature and the mixture was partitioned between water and ethyl acetate. The organic phase was separated and the aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product 4-phenyl-4H-1,2,4-triazole. | | References | [1] Tetrahedron, 2011, vol. 67, # 29, p. 5282 - 5288 |
| | 4-Phenyl-4H-1,2,4-triazole Preparation Products And Raw materials |
|