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| | PDZ1 DOMAIN INHIBITOR PEPTIDE Basic information |
| Product Name: | PDZ1 DOMAIN INHIBITOR PEPTIDE | | Synonyms: | PDZ1 DOMAIN INHIBITOR PEPTIDE;L-Valine, L-tyrosyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-alanyl-, (5→3)-lactam;Tyr-Lys-cyclo（Lys-Thr-Glu-β-Ala）-Val | | CAS: | 1315378-73-4 | | MF: | C38H61N9O11 | | MW: | 819.96 | | EINECS: | | | Product Categories: | | | Mol File: | 1315378-73-4.mol |  |
| | PDZ1 DOMAIN INHIBITOR PEPTIDE Chemical Properties |
| Boiling point | 1304.2±65.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | Soluble to 1 mg/ml in 5% acetonitrile / Water and to 4 mg/ml in DMSO | | pka | 3.36±0.10(Predicted) | | form | Solid | | color | White to off-white | | Sequence | Tyr-Lys-Lys-Thr-Glu-Ala-Val (Lactam bridge:Lys3-Glu5) |
| | PDZ1 DOMAIN INHIBITOR PEPTIDE Usage And Synthesis |
| Uses | PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1]. | | References | [1] Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11(4):469-73. DOI:10.1016/j.chembiol.2004.03.013 |
| | PDZ1 DOMAIN INHIBITOR PEPTIDE Preparation Products And Raw materials |
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