4-(4-Methyl-piperazin-1-yl)benzonitrile manufacturers
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| | 4-(4-Methyl-piperazin-1-yl)benzonitrile Basic information |
| Product Name: | 4-(4-Methyl-piperazin-1-yl)benzonitrile | | Synonyms: | 4-(4-METHYLPIPERAZINO)BENZONITRILE;AKOS B030325;4-(Methyl-piperazin-1-yl)benzonitrile;4-(4-Methyl-1-piperazinyl)benzonitrile;Benzonitrile, 4-(4-methyl-1-piperazinyl)-;4-(4-Methyl-piperazin-1-yl)benzonitrile | | CAS: | 34334-28-6 | | MF: | C12H15N3 | | MW: | 201.27 | | EINECS: | | | Product Categories: | | | Mol File: | 34334-28-6.mol |  |
| | 4-(4-Methyl-piperazin-1-yl)benzonitrile Chemical Properties |
| Melting point | 104-105℃ | | Boiling point | 356.5±37.0 °C(Predicted) | | density | 1.14 | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.62±0.42(Predicted) | | Appearance | White to light yellow Solid |
| | 4-(4-Methyl-piperazin-1-yl)benzonitrile Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 4-(4-methylpiperazin-1-yl)benzonitrile from N-methylpiperazine and p-fluorobenzonitrile was as follows: to a solution of dimethyl sulfoxide (7 mL) containing 4-fluorobenzonitrile (1.0 g, 8.25 mmol) and potassium carbonate (2.27 g, 16.51 mmol) was added 1-methylpiperazine (1.36 mL, 12.38 mmol). The reaction mixture was stirred at room temperature for the reaction. Upon completion of the reaction, the target product 4-(4-methylpiperazin-1-yl)benzonitrile (1.54 g, 93% yield) was obtained by conventional post-processing. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3) and ESI-MS: 1H-NMR δ 2.36 (3H, s), 2.55 (4H, t, J = 4.88 Hz), 3.35 (4H, t, J = 4.88 Hz), 6.87 (2H, d, J = 8.78 Hz), 7.49 (2H, d, J = 8.78 Hz); ESI-MS m/z 202.1 ([M+H]+). | | References | [1] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[2] Patent: WO2005/7625, 2005, A2. Location in patent: Page 63
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2008, vol. 183, # 5, p. 1252 - 1263
[4] Patent: WO2016/96709, 2016, A1. Location in patent: Page/Page column 50
[5] Patent: US2008/146542, 2008, A1. Location in patent: Page/Page column 36 |
| | 4-(4-Methyl-piperazin-1-yl)benzonitrile Preparation Products And Raw materials |
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