Dimethyl hydroxymethylphosphonate manufacturers
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| | Dimethyl hydroxymethylphosphonate Basic information |
| | Dimethyl hydroxymethylphosphonate Chemical Properties |
| Boiling point | 209℃ | | density | 1.245 | | Fp | 80℃ | | storage temp. | Inert atmosphere,Room Temperature | | pka | 12.73±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid | | InChI | InChI=1S/C3H9O4P/c1-6-8(5,3-4)7-2/h4H,3H2,1-2H3 | | InChIKey | OIERWUPLBOKSRB-UHFFFAOYSA-N | | SMILES | P(CO)(=O)(OC)OC | | CAS DataBase Reference | 24630-67-9(CAS DataBase Reference) |
| | Dimethyl hydroxymethylphosphonate Usage And Synthesis |
| Synthesis | Under stirring conditions, dimethyl phosphite (10.0 mL, 109 mmol), triethylamine (1.5 mL, 10.9 mmol) and paraformaldehyde (3.26 g) were mixed. The mixture was heated in an oil bath (external temperature) at 100°C. After 2.5 hours of reaction, the mixture was cooled to room temperature and subsequently concentrated under vacuum. The residue was purified by fast column chromatography (eluent: ethyl acetate/methanol, 95:5, v/v) to afford dimethyl hydroxymethylphosphonate as a colorless oil (9.41 g, 62% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.32 (1H, br s), 3.95 (2H, d, J = 6 Hz), 3.83 (3H, s), 3.81 (3H, s); 31P{1H} NMR (400.1 MHz, CDCl3): δ 27.8; 13C NMR (100.6 MHz. CDCl3): δ 53.5, 56.0, 57.6. | | References | [1] Journal of Polymer Science, Part A: Polymer Chemistry, 2012, vol. 50, # 12, p. 2432 - 2443
[2] Chemistry - A European Journal, 2009, vol. 15, # 9, p. 2064 - 2070
[3] Patent: WO2006/20779, 2006, A2. Location in patent: Page/Page column 77
[4] Organic Letters, 2012, vol. 14, # 18, p. 4798 - 4801
[5] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 3, p. 315 - 322 |
| | Dimethyl hydroxymethylphosphonate Preparation Products And Raw materials |
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