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Ethyl diethoxyphosphinylformate

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Ethyl diethoxyphosphinylformate Basic information
Product Name:Ethyl diethoxyphosphinylformate
Synonyms:Diethyl carbethoxyphosphonate;Diethyl ethoxycarbonylphosphonate;Ethyl diethoxyphosphinecarboxylate oxide;Formic acid, phosphono-, triethyl ester;phosphinecarboxylicacid,diethoxy-,ethylester,oxide;Triethyl carboxyphosphonate;Triethyl phosphonomethanoate;(ETHOXYCARBONYL)PHOSPHONIC ACID DIETHYL ESTER
CAS:1474-78-8
MF:C7H15O5P
MW:210.16
EINECS:216-016-8
Product Categories:Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds
Mol File:1474-78-8.mol
Ethyl diethoxyphosphinylformate Structure
Ethyl diethoxyphosphinylformate Chemical Properties
Boiling point 135 °C12 mm Hg(lit.)
density 1.11 g/mL at 25 °C(lit.)
refractive index n20/D 1.423(lit.)
Fp >230 °F
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Slightly)
color Colorless to Almost colorless
Specific Gravity1.11
BRN 1781949
Stability:Moisture Sensitive
InChI1S/C7H15O5P/c1-4-10-7(8)13(9,11-5-2)12-6-3/h4-6H2,1-3H3
InChIKeyNOJFJZZMRDSOLM-UHFFFAOYSA-N
CAS DataBase Reference1474-78-8(CAS DataBase Reference)
NIST Chemistry ReferencePhosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
EPA Substance Registry SystemPhosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-43
Safety Statements 24/25-36/37-26-37-24
WGK Germany 3
TSCA TSCA listed
HS Code 2931 39 90
Storage Class10 - Combustible liquids
MSDS Information
ProviderLanguage
Ethyl diethoxyphosphinylformate English
ACROS English
SigmaAldrich English
ALFA English
Ethyl diethoxyphosphinylformate Usage And Synthesis
Chemical PropertiesClear colorless to slightly yellow liquid
UsesDiethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
General Descriptionfor synthesis
Purification MethodsDissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]
Ethyl diethoxyphosphinylformate Preparation Products And Raw materials
Preparation ProductsFoscarnet sodium-->Foscarnet Impurity A
Tag:Ethyl diethoxyphosphinylformate(1474-78-8) Related Product Information
Tripropyl orthoformate Trimethyl phosphonoformate Ethyl methylphosphinate Ethyl methylphosphonic acid Methylphosphonic acid Methyldiethoxyphosphine Diethyl (hydroxymethyl)phosphonate Foscarnet Ethyl diethoxyphosphinylformate Diethyl methylphosphonate METHOXY CARBONYL PHOSPHONIC ACID PhosphonoMethanol METHYL METHYLPHOSPHONIC ACID Dimethyl methylphosphonate Dimethyl hydroxymethylphosphonate