4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
| 中文名称 | 4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯 |
|---|---|
| 中文同义词 | 4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯;芳卤芬酯;化合物ARHALOFENATE;阿卤芬酯;芳卤芬酯,10 MM DMSO 溶液 |
| 英文名称 | 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester |
| 英文同义词 | MBX 102;JNJ 39659100;(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)-;4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-;MBX-102 >=98% (HPLC);JNJ-39659100,MBX102,Arhalofenate,Inhibitor,MBX-102,inhibit,PPAR,Peroxisome proliferator-activated receptors,JNJ39659100 |
| CAS号 | 24136-23-0 |
| 分子式 | C19H17ClF3NO4 |
| 分子量 | 415.79 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 24136-23-0.mol |
| 结构式 | ![4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯 结构式](CAS2/GIF/24136-23-0.gif) |
4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯 性质
| 沸点 | 551.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.331 |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥35mg/mL |
| 酸度系数(pKa) | 15.32±0.46(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
| InChI | 1S/C19H17ClF3NO4/c1-12(25)24-9-10-27-18(26)17(13-5-7-15(20)8-6-13)28-16-4-2-3-14(11-16)19(21,22)23/h2-8,11,17H,9-10H2,1H3,(H,24,25)/t17-/m1/s1 |
| InChIKey | BJBCSGQLZQGGIQ-QGZVFWFLSA-N |
| SMILES | FC(F)(F)c1cc(ccc1)O[C@H](c2ccc(cc2)Cl)C(=O)OCCNC(=O)C |
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PPAR-γ
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Arhalofenate (MBX 102) is a prodrug ester, that is rapidly and completely modified in vivo by non-specific serum esterases to the mature free acid form Arhalofenate (MBX 102) acid. Arhalofenate (MBX 102) shows a dose-dependent activation of mouse GAL4-PPAR-γ with EC 50 s of appr 12 μM.
Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly increases the glucose infusion rate and decreases hepatic glucose output in the clamped state in Zucker Diabetic Fatty (ZDF) rats. Arhalofenate (MBX 102) (60 mg/kg) leads to a dramatic decrease in plasma and also results in a dose-dependent, significant decrease in the insulin resistance indexinsulin levels. Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly decreases triglyceride, free fatty acid, and cholesterol levels in ZDF rats. MBX-102 significantly reduces fasting blood glucose, confirming that Arhalofenate (MBX 102) is an efficacious antidiabetic agent. Arhalofenate (MBX 102) (100 mg/kg, p.o.) also significantly lowers fasting plasma insulin, and robustly decreases fasting plasma triglycerides after 32 days of treatment in Zucker Fatty (ZF) rats.
安全信息
| 危险品标志 | T,N |
|---|---|
| 危险类别码 | 25-36-50/53 |
| 安全说明 | 26-45-60-61 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| 存储类别 | 6.1C - 可燃，急性毒性 类别3 毒性化合物或者引起慢性影响的化合物 |
| 危险性类别 | 急性毒性 类别3经口 危害水生环境-急性危害 类别1 眼部刺激 类别2 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-14831 | Arhalofenate | 24136-23-0 | 1 mg | 1300元 |
| 2026/06/05 | HY-14831 | 4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯 Arhalofenate | 24136-23-0 | 5 mg | 2920元 |