N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Request For Quotation
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: Hangzhou Sage Chemical Co., Ltd.  
Tel: +86057186818502 13588463833
Email: info@sagechem.com
Company Name: Chengdu NoVi Biotechnology Co., Ltd.  
Tel: 028-81458053
Email: novibiotech@163.com sales@novi-biotech.com
Company Name: SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD  
Tel: 13816107857
Email: sales@fortunechem-sh.com
Company Name: AdooQ BioScience, LLC   
Tel: +1 (866) 930-6790
Email: info@adooq.com

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers

  • JK184
  • JK184 pictures
  • $30.00
  • 2026-07-14
  • CAS:315703-52-7
  • Purity: 99.09%
  • Supply Ability: 10g
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Basic information
Product Name:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
Synonyms:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine;Hh Signaling Antagonist VII, JK184;JK 184;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;CS-2369;JK184 (JK-184
CAS:315703-52-7
MF:C19H18N4OS
MW:350.44
EINECS:
Product Categories:
Mol File:315703-52-7.mol
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Structure
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemical Properties
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO: ≥20mg/mL
form powder
color off-white to light brown
InChI1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
InChIKeyROYXIPOUVGDTAO-UHFFFAOYSA-N
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-36
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Usage And Synthesis
UsesJK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
UsesJK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.
Biological ActivityPotent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .
in vivo

JK184 (5 mg/kg, injected intravenously) exhibits good anti-proliferative activity in subcutaneous Panc-1 and BxPC-3 tumor models, and is a good candidate as antitumor drug targeted Hh signaling. However, JK184 has a poor pharmacokinetic profile and bioavailability[1].

storage+4°C
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Preparation Products And Raw materials
Tag:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine(315703-52-7) Related Product Information
N-Methylformamide FORMANILIDE 4-Aminodiphenylamine N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine PTC-209 (PTC209 4-[[4-(2,7-DiMethyliMidazo[1,2-a]pyridin-3-yl)-2-thiazolyl]aMino]benzoic Acid