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| | Tramadol hydrochloride Basic information |
| | Tramadol hydrochloride Chemical Properties |
| Melting point | 178-181 °C | | storage temp. | 2-8°C | | solubility | Freely soluble in water and in methanol, very slightly soluble in acetone. | | form | solid | | pka | 9.41 | | color | white to off-white | | InChI | 1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1 | | InChIKey | PPKXEPBICJTCRU-XMZRARIVSA-N | | SMILES | Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C |
| Hazard Codes | Xn,N | | Risk Statements | 22-51/53 | | Safety Statements | 61 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 2 | | HS Code | 2922504500 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Aquatic Chronic 2
STOT SE 3 | | Toxicity | mouse,LD50,intravenous,61700ug/kg (61.7mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 114, 1978. |
| | Tramadol hydrochloride Usage And Synthesis |
| Description | cis-Tramadol (Item No. 15919) is an analytical reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications. | | Description | cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is a certified reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is provided as a DEA exempt preparation. This product is intended for research and forensic applications. | | Chemical Properties | White Solid | | Uses | cis-Tramadol is an analgesic that activates the μ-opioid receptor (IC50 = 7.6 μM). It also inhibits serotonin and norepinephrine reuptake and blocks voltage-gated sodium channels. This product is intended for forensic and research applications.[Cayman Chemical] | | Uses | An analgesic. | | Definition | ChEBI: (R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist and a serotonin uptake inhibitor. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride. | | References | [1] LIMING SHAO. Derivatives of tramadol for increased duration of effect[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 3: Pages 691-694. DOI: 10.1016/j.bmcl.2005.10.024 |
| | Tramadol hydrochloride Preparation Products And Raw materials |
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