5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

62009-33-0

73183-34-3

1083326-26-4

GENERAL STEPS: A mixture of 5-bromopyridine-3-sulfonamide (6.33 mmol), bis(pinacolato)diboron (6.96 mmol), potassium acetate (18.99 mmol), and dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.32 mmol) was dissolved in 1,4-dioxane (15 mL). The reaction mixture was placed in a microwave reactor and irradiated at 120 °C for 40 min. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and washed with dioxane. The filtrate was concentrated under reduced pressure to afford 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide as a brown solid (quantitative yield). The mass spectrum (electrospray ionization, positive ion mode) showed m/z 203 [M + H]+, corresponding to the molecular ion peak of the target compound. In addition, the residue could be further purified by grinding in dichloromethane to give a light brown solid.1H NMR (400 MHz, DMSO-d6) δ ppm: 8.76 (s, 2H), 8.22 (s, 1H), 7.45 (br s, 2H), 1.13 (s, 12H).