9,11-methane-epoxy Prostaglandin F1α

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9,11-methane-epoxy Prostaglandin F1α Basic information
Product Name:9,11-methane-epoxy Prostaglandin F1α
Synonyms:9,11-methane-epoxy Prostaglandin F1α;9,11-methane-epoxy Prostaglandin 1α;VGRVXLWYKKBTNM-KQMLLPOFSA-N;9,11-methane-epoxy Prostaglandin F1.alpha.;9,11-methane-epoxy Prostaglandin 1alpha;2-Oxabicyclo[2.2.1]heptane-5-heptanoic acid, 6-(3-hydroxy-1-octenyl)-, [1α,4α,5β,6α(1E,3S*)]- (9CI);9,11-methane-epoxy Prostaglandin 1α
CAS:72517-81-8
MF:C21H36O4
MW:352.51
EINECS:
Product Categories:
Mol File:72517-81-8.mol
9,11-methane-epoxy Prostaglandin F1α Structure
9,11-methane-epoxy Prostaglandin F1α Chemical Properties
Boiling point 519.077±25.00 °C(Press: 760.00 Torr)(predicted)
density 1.077±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
pka4.777±0.10(predicted)
Safety Information
MSDS Information
9,11-methane-epoxy Prostaglandin F1α Usage And Synthesis
DescriptionProstaglandin (PG) endoperoxides are intermediates in the biosynthesis of PGs, thromboxanes, and prostacyclin. The endoperoxides, PGH2 and PGG2, induce rapid and irreversible aggregation of human platelets.1 PGH1 and PGG1 are known to contract smooth muscle preparations, but are lacking in aggregatory effects. 9,11-methane-epoxy Prostaglandin F1α (9,11-methane-epoxy PGF1α) is a stable epoxymethano analog of PGH1 that produces a strong and dose-related aggregation of washed rabbit platelets (EC50 = 0.88 μM) and contraction of rabbit aortic strips (EC50 = 0.11 μM).1 9,11-methane-epoxy PGF1α induces contraction of guinea pig tracheas (EC50 = 3.4 μM) with a maximal contraction of about 60% of that caused by a submaximal dose of histamine.
References1. Morita, A., Nishino, H., Hasegawa, K., et al. Biological activities of prostaglandin H1 analogs Prostaglandins 18(4),529-540(1979).
9,11-methane-epoxy Prostaglandin F1α Preparation Products And Raw materials
Tag:9,11-methane-epoxy Prostaglandin F1α(72517-81-8) Related Product Information
15(R)-Prostaglandin F1α 6,15-DIKETO-13,14-DIHYDRO PROSTAGLANDIN F1ALPHA 15(S)-15-METHYL PROSTAGLANDIN D2 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α Cyclopentanepentanoic acid, 3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-, (1S,2R,3R,5S)- AMP-PNP lithium hydrate